(1-methylethyl)boronic acid
Isopropylboronic acid
CAS: 80041-89-0
Molecular Formula: C3H9BO2
(1-methylethyl)boronic acid - Names and Identifiers
| Name | Isopropylboronic acid |
| Synonyms | Isopropylboronic RARECHEM AH PB 0254 ISOPROPYLBORONIC ACID 2-PROPANEBORONIC ACID 2-Propaneboronic acid Isopropylboronic acid PROPANE-2-BORONIC ACID (propan-2-yl)boronic acid (1-methylethyl)boronic acid (1-Methylethyl)boronic acid |
| CAS | 80041-89-0 |
| EINECS | 676-846-5 |
| InChI | InChI=1/C3H9BO2/c1-3(2)4(5)6/h3,5-6H,1-2H3 |
(1-methylethyl)boronic acid - Physico-chemical Properties
| Molecular Formula | C3H9BO2 |
| Molar Mass | 87.91 |
| Density | 0.921±0.06 g/cm3(Predicted) |
| Melting Point | 95-100 °C (lit.) |
| Boling Point | 160.4±23.0 °C(Predicted) |
| Flash Point | 50.8°C |
| Water Solubility | Soluble in water. |
| Vapor Presure | 0.833mmHg at 25°C |
| Appearance | Flakes |
| Color | White |
| BRN | 1731883 |
| pKa | 10.49±0.43(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Sensitive | Hygroscopic |
| Refractive Index | 1.385 |
| MDL | MFCD03789259 |
| Use | Reactant or reagent involved in: 1.Copper-promoted cross-coupling. 2.Domino Heck-Suzuki reactions. 3.C-H activation for arylations and alkylations. 4.Suzuki-Miyaura type couple reactions. 5.Alkylation-hydride reduction sequence. |
(1-methylethyl)boronic acid - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29163990 |
(1-methylethyl)boronic acid - Introduction
Isopropylboronic acid, also known as isopropionic acid, is an organoboron compound. The following is an introduction to the nature, use, preparation and safety information of Isopropylboronic acid:
Nature:
- Isopropylboronic acid is a colorless crystalline solid, soluble in some organic solvents such as ether and methanol;
-It is a weak acid that can neutralize with alkali;
-Relatively stable in the air, but may decompose under high temperature or light;
- Isopropylboronic acid can form a variety of complexes, and participate in organic synthesis reaction.
Use:
- Isopropylboronic acid is commonly used as a reagent in organic synthesis, especially for Suzuki-Miyaura-catalyzed coupling reactions of ketones and aldehydes;
-It can be used to synthesize organic compounds such as drugs, pesticides, coupling agents and functional molecules;
- Isopropylboronic acid can also be used for catalytic oxidation reaction, coupling reaction and hydrogenation reaction.
Preparation Method:
Isopropylboronic acid can be prepared by the following methods:
-reaction 1: it can be obtained by reacting propylene ketone with boric acid;
-Reaction 2: It can be obtained by reacting allyl alcohol with tributyl borate.
Safety Information:
- Isopropylboronic acid has less impact on human body and environment in general;
-in the use of Isopropylboronic acid, should comply with the laboratory safety procedures, wear protective glasses and gloves;
-avoid inhalation of Isopropylboronic acid vapor and dust, avoid direct contact with the skin;
-If exposed or inhaled, rinse immediately with water or seek medical help.
Nature:
- Isopropylboronic acid is a colorless crystalline solid, soluble in some organic solvents such as ether and methanol;
-It is a weak acid that can neutralize with alkali;
-Relatively stable in the air, but may decompose under high temperature or light;
- Isopropylboronic acid can form a variety of complexes, and participate in organic synthesis reaction.
Use:
- Isopropylboronic acid is commonly used as a reagent in organic synthesis, especially for Suzuki-Miyaura-catalyzed coupling reactions of ketones and aldehydes;
-It can be used to synthesize organic compounds such as drugs, pesticides, coupling agents and functional molecules;
- Isopropylboronic acid can also be used for catalytic oxidation reaction, coupling reaction and hydrogenation reaction.
Preparation Method:
Isopropylboronic acid can be prepared by the following methods:
-reaction 1: it can be obtained by reacting propylene ketone with boric acid;
-Reaction 2: It can be obtained by reacting allyl alcohol with tributyl borate.
Safety Information:
- Isopropylboronic acid has less impact on human body and environment in general;
-in the use of Isopropylboronic acid, should comply with the laboratory safety procedures, wear protective glasses and gloves;
-avoid inhalation of Isopropylboronic acid vapor and dust, avoid direct contact with the skin;
-If exposed or inhaled, rinse immediately with water or seek medical help.
Last Update：2024-04-09 15:18:00
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